abstract：:Cyanobacteria are a diverse group of Gram-negative bacteria that produce an array of secondary compounds with selective bioactivity against vertebrates, invertebrates, plants, microalgae, fungi, bacteria, viruses and cell lines. The aim of this study was to assess the toxic effects of aqueous, methanolic and hexane cr...

journal_title：Marine drugs

authors： Lopes VR,Fernández N,Martins RF,Vasconcelos V

更新日期：2010-03-05 00:00:00

abstract：:Preliminary biological investigation of a collection of Comorian soft corals resulted in the selection of two specimens, one of Sarcophyton and the other of Lobophytum, on the basis of their toxicity on larvae of the brine shrimp (Artemia salina) and inhibition of acetylcholinesterase, respectively. Bioassay-guided fr...

journal_title：Marine drugs

authors： Bonnard I,Jhaumeer-Laulloo SB,Bontemps N,Banaigs B,Aknin M

更新日期：2010-02-23 00:00:00

abstract：:In this study, thirteen sponge-derived terpenoids, including five linear furanoterpenes: furospinulosin-1 (1), furospinulosin-2 (2), furospongin-1 (3), furospongin-4 (4), and demethylfurospongin-4 (5); four linear meroterpenes: 2-(hexaprenylmethyl)-2-methylchromenol (6), 4-hydroxy-3-octaprenylbenzoic acid (7), 4-hydro...

journal_title：Marine drugs

authors： Orhan I,Sener B,Kaiser M,Brun R,Tasdemir D

更新日期：2010-01-15 00:00:00

abstract：:Sponges can provide potential drugs against many major world-wide occurring diseases. Despite the high potential of sponge derived drugs no sustainable production method has been developed. Thus far it is not fully understood why, when, where and how these metabolites are produced in sponges. For the near future sea-b...

journal_title：Marine drugs

authors： Koopmans M,Martens D,Wijffels RH

更新日期：2009-12-02 00:00:00

abstract：:N,N-Didesmethylgrossularine-1 (DDMG-1), a compound with a rare alpha-carboline structure, was isolated from an Indonesian ascidian Polycarpa aurata as responsible for the observed inhibitory activity against TNF-alpha production in lipopolysaccharide-stimulated murine macrophage-like RAW264.7 cells. DDMG-1 inhibited t...

journal_title：Marine drugs

authors： Oda T,Lee JS,Sato Y,Kabe Y,Sakamoto S,Handa H,Mangindaan RE,Namikoshi M

更新日期：2009-11-17 00:00:00

abstract：:Crude extracts and column fractions from the red algae Asparagopsis taxiformis and A. armata from the Strait of Messina (Italy) were screened for the production of antimicrobial compounds. Extracts from both species revealed remarkable antiprotozoal activity against Leishmania, revealing such algae as a great source o...

journal_title：Marine drugs

authors： Genovese G,Tedone L,Hamann MT,Morabito M

更新日期：2009-08-11 00:00:00

abstract：:Investigation of minor metabolites in the extracts of the red alga Sphaerococcus coronopifolius collected from the rocky coasts of Corfu Island in the Ionian Sea yielded two new diterpene alcohols, sphaerollanes I, and II (1, 2) featuring neodolabellane skeletons, and the new sphaeroane diterpene alcohol 16-hydroxy-9S...

journal_title：Marine drugs

authors： Smyrniotopoulos V,Vagias C,Roussis V

更新日期：2009-05-19 00:00:00

abstract：:D. salina is one of the recognized natural sources to produce beta-carotene, and an useful model for studying the role of inhibitors and enhancers of carotenogenesis. However there is little information in D. salina regarding whether the isoprenoid substrate can be influenced by stress factors (carotenogenic) or selec...

journal_title：Marine drugs

authors： Paniagua-Michel J,Capa-Robles W,Olmos-Soto J,Gutierrez-Millan LE

更新日期：2009-01-01 00:00:00

abstract：:Paralytic shellfish poisoning (PSP), due to saxitoxin and related compounds, typically results from the consumption of filter-feeding molluscan shellfish that concentrate toxins from marine dinoflagellates. In addition to these microalgal sources, saxitoxin and related compounds, referred to in this review as STXs, ar...

journal_title：Marine drugs

authors： Deeds JR,Landsberg JH,Etheridge SM,Pitcher GC,Longan SW

更新日期：2008-06-10 00:00:00

abstract：:Azaspiracids (AZA) are polyether marine toxins that accumulate in various shellfish species and have been associated with severe gastrointestinal human intoxications since 1995. This toxin class has since been reported from several countries, including Morocco and much of western Europe. A regulatory limit of 160 micr...

journal_title：Marine drugs

authors： Twiner MJ,Rehmann N,Hess P,Doucette GJ

更新日期：2008-05-07 00:00:00

abstract：:Domoic acid is a marine biotoxin associated with harmful algal blooms and is the causative agent of amnesic shellfish poisoning in marine animals and humans. It is also an excitatory amino acid analog to glutamate and kainic acid which acts through glutamate receptors eliciting a very rapid and potent neurotoxic respo...

journal_title：Marine drugs

authors： Gill SS,Hou Y,Ghane T,Pulido OM

更新日期：2008-02-14 00:00:00

abstract：:Smenospongine, a sesquiterpene aminoquinone isolated from the marine sponge Dactylospongia elegans, was previously reported by us to induce erythroid differentiation and G1 phase arrest of K562 chronic myelogenous leukemia cells. In this study, we investigated the effect of smenospongine on the cell cycles of other le...

journal_title：Marine drugs

authors： Kong D,Aoki S,Sowa Y,Sakai T,Kobayashi M

更新日期：2008-01-01 00:00:00

abstract：:The immunotoxic potential of domoic acid (DA), a well-characterized neurotoxin, has not been fully investigated. Phagocytosis and lymphocyte proliferation were evaluated following in vitro and in vivo exposure to assay direct vs indirect effects. Mice were injected intraperitoneally with a single dose of DA (2.5 micro...

journal_title：Marine drugs

authors： Levin M,Leibrecht H,Ryan J,Van Dolah F,De Guise S

更新日期：2008-01-01 00:00:00

abstract：:Polymeric 3-alkylpyridinium salts (poly-APS) present in the marine sponge Reniera sarai show a broad spectrum of biological activities. They are lytic to erythrocytes and various other mammalian cells, enabling the transfection of the latter with alien DNA. Furthermore, they show inhibitory effects to marine bacteria ...

journal_title：Marine drugs

authors： Turk T,Frangez R,Sepcić K

更新日期：2007-11-13 00:00:00

abstract：:Many cytotoxic compounds of therapeutic interest have been isolated from marine invertebrates, and some of them have been reported to be of microbial origin. Pyridoacridine alkaloids are the main compounds extracted from the ascidian Cystodytes dellechiajei. Here we describe the in vitro antiproliferative activity aga...

journal_title：Marine drugs

authors： Martinez-García M,Diaz-Valdés M,Ramos-Esplá A,Salvador N,Lopez P,Larriba E,Antón J

更新日期：2007-07-19 00:00:00